Our main interest is in quantitative MRI of the brain, and relating these quantitative maps to microstructural features of the tissue. Methodological developments include novel image acquisition techniques, multi-modal biophysical modelling, and high-resolution cortical imaging. The lab has a translational approach, working on both small animal (7 Tesla) and human (3 and 7 Tesla) MRI systems.

Many of the studies in the lab are related to myelin, a fatty substance that forms an electrically insulating sheath around axons to achieve and maintain the rapid conduction and synchronous timing of neural networks. Myelination is a lifelong dynamic process of forming and remodelling myelin sheaths. It underlies key mechanisms of brain plasticity and higher order cognitive functions. In addition to demyelinating diseases such as multiple sclerosis, there is accumulating evidence that dysmyelination contributes to psychiatric disorders as well. The lab investigates myelination (in both white and grey matter) using multiple MRI techniques such as relaxometry, magnetization transfer and diffusion-weighted imaging. 

 

Our research is kindly supported by