Current projects
Group average T1 mapped onto an inflated cortical surface.
imaging cortical microstructure
We develop high-resolution quantitative imaging techniques to investigate the microstructure of the cortex in vivo. This work is mainly performed at ultra-high magnetic field (7 Tesla). Our previous work has focused on T1 mapping. We are now working on combining multiple MRI contrasts using biophysical models to enhance microstructural specificity.
white matter tract-specific myelin imaging
Diffusion imaging is extensively used to investigate the structural connectivity and microstructure of the brain. Diffusion is complementary to myelin imaging techniques, such as relaxometry and magnetization transfer. These contrast mechanisms can be combined during data acquisition, or during image analysis, to map the microstructural features of specific white matter fibre populations.
Inversion-recovery prepared diffusion-weighted images.
Coronal magnetization transfer ratio (MTR) image of a mouse brain at 7 Tesla.
Myelin Plasticity
Oligodendrocytes and the myelin they produce are much more dynamic than originally though. Myelination is a life-long process, that is affected by neuronal activity and experience, and contributes to learning. We are using quantitative MRI to investigate myelin plasticity in mice.